The Orchestra of the Haute école de musique de Genève-Neuchâtel is made up of students from the institution. It benefits from partnerships with renowned professional ensembles in the Lake Geneva region and from the interest of renowned conductors. International tours are undertaken every year. In 2009, the orchestra went on a concert tour in China and in February 2010, it performed Frank Martin's Cinderella's Tale at the Palace of Arts Theatre in Budapest under the direction of Gábor Takács-Nagy.

In autumn 2013, the EMH Orchestra toured Japan in partnership with the Tokyo University of the Arts. Then, in the summer of 2015, in collaboration with the Haute école de musique de Lausanne and the Singapore Conservatory, it played on the main stage of the Paléo Festival and at the Esplanade in Singapore under the baton of Thierry Fischer with the young and talented pianist Louis Schwizgebel.

In the spring of 2016, the EMH Orchestra, in collaboration with the ZHDK Orchestra, gave the Swiss premiere of Glière's 3rd Symphony under the baton of the renowned Russian conductor Yuri Simonov for the 10th Orchestra Academy, which has brought the two schools together for the past twenty years. The orchestra collaborates with the OSR and Contrechamps every season.

The EMH Orchestra performs works by contemporary composers. These composers work closely with the students. The orchestra is conducted by renowned conductors such as Nader Abbassi, Leonardo García Alarcón, Pierre-André Valade and Domingo Garcia Hindoyan. In 2018-2019, the EMH welcomed Pierre Bleuse, Nicolas Farine, Pierre Fouchenneret, Laurent Gay, Yann Kerninon, Pierre-Antoine Marçais, Julien Salemkour and Gábor Takács-Nagy.