Born in 1985 in Milan, Matteo De Luca began his studies at the age of 9. He studied trombone at the Giuseppe-Verdi Conservatory in Milan, where he graduated in 2005 with honours. From 2006 to 2007 he studied with Conrad Colliard at the Guido-Cantelli Conservatory in Novara, and in 2008 he was admitted to the Geneva Conservatory of Music in Andrea Bandini's class for the Soloist's Master's degree. He won the First Prizes at the International Competitions in Chieri in 2006 and Riddes in 2007. From 2007 to 2009, Matteo De Luca was a member of the UBS Orchestra of the Verbier Festival. In 2009 he won the Principal Trombone Competition at the Royal Philharmonic Orchestra in London and in September 2010 he won the Principal Trombone Competition at the North Opera Orchestra in Leeds. He finally joined the Orchestre de la Suisse Romande in December 2010, also as principal trombone.

He is invited as principal trombone in several orchestras, such as the Orchestra of the Royal Theatre of Turin, the RAI National Symphony Orchestra, the Orchestra de la Scala, the Symphony Orchestra of Bern, the National Orchestra of Porto and the Hong Kong Sinfonietta.