Cheryl House Brun studied with Gabor Rejto at the University of Southern California (USC) with William Pleeth, with Jacqueline Du Pré in London and with Lynn Harrel at the Juilliard School, where she obtained a Master of Music degree in 1984. She was awarded the Special Prize for the best interpretation of a Russian work at the Tchaikovsky Competition, and is a prizewinner at the Phi Epsilon International Competition, where she has participated in numerous concerts in the United States. Cheryl House Brun records for several American television stations and European radio stations.
In 1989, Gidon Kremer invited her to play at the Lockenhaus Festival in Austria. Member of the Orchestre de la Suisse Romande, she also plays as a soloist and in chamber music formations, most notably with the Prima Carezza ensemble, which won the Grand Prix de l'Académie Charles-Cros for its recording Extase. Cheryl House Brun plays a Storioni cello from the Cremona School (1750).